Top MedTech Startups in the US

The United States is home to some of the most innovative MedTech startups in the world. These companies are revolutionising healthcare through cutting-edge technology, from AI-driven diagnostics to advanced surgical robotics. In this blog, we explore the top MedTech startups making waves across America.

Is MedTech in Demand in the US?

The MedTech industry in the USA accounts for 2 million jobs, and due to the relentless advancement of innovative health technologies, it is likely that the sector will keep generating job opportunities for the foreseeable future.

What is the Future of MedTech in the US?

The primary source of innovation at larger medtech companies will remain the acquisition of new technologies and capabilities. The U.S. healthcare system will continue to focus on costs, with ongoing efforts to promote home health and remote options to prevent patients from entering the costly hospital environment.

Top MedTech Startups in the US

The US MedTech scene is growing and will continue to grow. With this growth, more and more MedTech startups are popping up all over the US. Here are the top startups in MedTech:

1. Axena Health

Axena Health is a women’s health organisation that is transforming the care standard for pelvic health issues with clinically validated, non-invasive treatments. The doctor-recommended Leva Pelvic Health System enables women to engage in effective, monitored pelvic floor muscle training at home, integrating advanced motion-based technology with treatments backed by scientific evidence and individualised coaching.

2. MEDvidi

MEDvidi is a telehealth platform that establishes a new benchmark for mental health care in the United States, prioritising safety, effectiveness, and scalability. MEDvidi provides reliable, results-oriented treatment for conditions such as ADHD, anxiety, depression, and insomnia, leveraging the expertise of licensed medical professionals and proprietary AI systems. Their focus encompasses mental health evaluation and evidence-based medication management, ensuring that every visit is guided by data rather than guesswork.

3. Nine Diagnostics

Nine Diagnostics is developing a nanosensor platform powered by AI, which allows for real-time measurement of biological processes. They convert dynamic molecular activity into actionable insights, assisting clinicians and biopharma teams in determining whether a treatment is effective, understanding its effectiveness, and making adjustments sooner. They aim to assist each patient in attaining the appropriate treatment more quickly by converting intricate biological signals into straightforward, actionable information.

4. EmoWise Project

EmoWise is an innovative platform offering automated neuromodulation to alleviate negative emotions and stress. In an era where chronic stress is the norm, negatively affecting our health, productivity, and clarity of thought, EmoWise provides a distinctive proactive remedy.

They have created an intelligent AI core system that incorporates biometric wearable sensors. EmoWise provides continuous real-time monitoring of physiological stress markers.

5. Luxora Med

Luxora Med develops diagnostic products that prioritise cultural sensitivity and privacy, aiming to eliminate the shame and obstacles associated with testing for stigmatised conditions such as HIV.

Their leading product is the first self-test kit that provides encrypted, at-home results with verifiable proof, without the need for internet access or clinic visits. Users can select saliva, blood, or urine samples and receive results within 15 minutes. Results are interpreted offline through AI, encrypted using biometrics, and saved as a zero-knowledge health credential (ZK-NFT).

6. MeducateX

MeducateX serves as an AI-powered surgical education platform, converting actual surgeries into organised learning experiences for surgeons, residents, and medical institutions. They operate directly within actual operating rooms, recording multi-angle, high-definition surgical footage and transforming it into educational modules that are AI-annotated and organised by steps.

7. RephImmune

RephImmune Biotechnology is a company in the preclinical phase that is working on next-generation engineered immune cell therapies aimed at addressing the shortcomings of existing cell therapies for solid tumours.

Their key technology, the RACE platform, is a modular solution that does not use CARs and combines BiTE-like engagement with unique novel signalling domains. RACE offers flexible targeting options, improved safety profiles, enhanced persistence, and strong anti-tumour potency by decoupling target recognition from activation circuitry.

8. XBrainer AI

XBrainer AI is developing neural security infrastructure for brain-computer interfaces (BCIs), beginning with non-invasive systems based on EEG. Their platform allows for real-time validation and enforcement of safety policies at the signal level, tackling existing gaps in neural data integrity and consent enforcement. With little verification or control, consumer neurodevices stream raw brain data to cloud services, exposing users to risks like unauthorised signal manipulation, biometric profiling, or synthetic intent injection.